468 MICROSCALE GUIDANCE FOR OPTIMAL HUMAN MESENCHYMAL STEM CELL-BASED CHONDROGENESIS
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem Cell-Based Tissue Engineering for Chondrogenesis
In tissue engineering fields, recent interest has been focused on stem cell therapy to replace or repair damaged or worn-out tissues due to congenital abnormalities, disease, or injury. In particular, the repair of articular cartilage degeneration by stem cell-based tissue engineering could be of enormous therapeutic and economic benefit for an aging population. Bone marrow-derived mesenchymal ...
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Ultrasound at 5.0 MHz was noted to be chondro-inductive, with improved SOX-9 gene and COL2A1 protein expression in constructs that allowed for cell-to-cell contact. To achieve tissue-engineered cartilage using macroporous scaffolds, it is hypothesized that a combination of ultrasound at 5.0 MHz and transforming growth factor-β3 induces human mesenchymal stem cell differentiation to chondrocytes...
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Mesenchymal stem cells (MSCs) have the capacity to self-renew and differentiate into multiple cell types, but little is known about the precise mechanism of this procedure. Recent studies show that a group of short noncoding RNAs called microRNAs (miRNAs) play a key role in this procedure. However, little work has been done to determine the miRNAs which specifically regulate the differentiation...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2011
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(11)60495-0